6月份国内新出的细胞外囊泡/外泌体领域论文不完全统计有465篇。IF>10的有119篇；IF>20的有26篇。本期主要内容包括：肺纤维化治疗、抗衰祖细胞疗法、辐射后导致骨骼肌无力的机制、阿尔茨海默病、风湿性关节炎、胰腺癌、直肠癌肝前转移微环境、脑缺血再灌注损伤、中风、仑伐替尼耐药、感染性伤口愈合、牙髓炎、胶质母细胞瘤、结肠炎、组织再生等方面内容。内容十分丰富，不容错过。外泌体之家搜集整理。本期发表文章较多的杂志有Bioact Mater（8）、ACS Nano（7）、J Extracell Vesicles（6）、Adv Sci (Weinh)（10）、J Nanobiotechnology（9）、J Control Release（5）、Mater Today Bio（11）等。
1.清华大学基础医学院常智杰课题组开发肺纤维化治疗新方法并完成I期临床试验
Li, M., et al. (2025). "Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment."
Signal Transduct Target Ther 10(1): 179. IF=52.7
前期报道：https://www.exosomemed.com/19513.html
2.中国科学院动物研究所刘光慧研究组、曲静研究组,联合首都医科大学宣武医院王思课题组：灵长类通用抗衰祖细胞疗法
Lei, J., et al. (2025). "Senescence-resistant human mesenchymal progenitor cells counter aging in primates."
Cell. IF=42.5
该研究成功构建了兼具抗衰老、抗应激和抗恶性转化能力的工程化人类抗衰型间充质祖细胞（SRC），并在灵长类动物模型中验证了其延缓多器官衰老的效果。机制探究表明，SRC释放的外泌体在促进细胞年轻化、抑制慢性炎症以及维持基因组与表观基因组稳定性方面发挥了核心作用。
3.【综述】南方医科大学刘友华：纤维化疾病中的成纤维细胞激活与异质性
Zhang, X., et al. (2025). "Fibroblast activation and heterogeneity in fibrotic disease."
Nat Rev Nephrol. IF=39.8
4.【综述】香港大学Alice S. T. Wong：癌症纳米医学中的外泌体——生物技术的进展与创新
Liu, J. J. J., et al. (2025). "Exosomes in cancer nanomedicine: biotechnological advancements and innovations."
Mol Cancer 24(1): 166.IF=33.9
5.【综述】大连理工大学李盛龙：细胞外囊泡——乳腺癌宿主微环境中的“特洛伊木马”
Kang, Y., et al. (2025). "Extracellular vesicles: the "Trojan Horse" within breast cancer host microenvironments."
Mol Cancer 24(1): 183. IF=33.9
6.重庆医科大学钟雯：中国西部一项多中心前瞻性出生队列研究
Li, X., et al. (2025). "A multi-centered prospective birth cohort study in Western China."
Imeta 4(3): e70049. IF=33.2
7.武汉大学闫卫：花生四烯酸触发原发性肿瘤分泌亚精胺合酶，从而在辐射后导致骨骼肌无力
Zhang, X., et al. (2025). "Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation."
Cell Metab. IF=30.9
8.南方医科大学汪枭睿：脂质化纳米光敏剂追踪并抑制肿瘤细胞外囊泡，同时抑制肿瘤生长和转移
Miao, G., et al. (2025). "Concurrent inhibition of tumor growth and metastasis by a lipidated nanophotosensitizer tracing and disabling tumor extracellular vesicles."
Nat Cancer. IF=28.5
9.广东以色列理工学院郭克迎：通过对多种血液细胞外囊泡生物标志物进行单分子生物电子无标记分析实现阿尔茨海默病的临床精准诊断
Zheng, J., et al. (2025). "Clinically Accurate Diagnosis of Alzheimer's Disease via Single-Molecule Bioelectronic Label-Free Profiling of Multiple Blood Extracellular Vesicle Biomarkers."
Adv Mater: e2505262.IF=26.8
10.四川大学程冲：用于精确调节炎症和免疫稳态以对抗类风湿性关节炎的生物催化和氧化还原调控纳米结构
Xiao, S., et al. (2025). "Biocatalytic and Redox-Regulated Nanoarchitectures for Precision Inflammation and Immune Homeostasis Modulation to Combat Rheumatoid Arthritis."
Adv Mater: e2502147.IF=26.8
11.天津大学-新加坡国立大学福州联合学院刘斌：一种以代谢为导向的策略，用于直接从癌细胞中生成经光敏剂改造的细胞外囊泡
Wang, D., et al. (2025). "A Metabolism-Oriented Strategy to Directly Generate Photosensitizer-Engineered Extracellular Vesicles from Cancer Cells."
Adv Mater: e2505726. IF=26.8
12.复旦大学附属肿瘤医院虞先濬、施思团队：组蛋白乳酸化驱动的反馈回路调节胰腺癌中与胆固醇相关的免疫抑制
Yang, J., et al. (2025). "Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer."
Gut. IF=25.8
13.西南医科大学附属医院李俊：加强胃癌的非侵入性早期检测——对外泌体非编码RNA和机器学习的批判性反思
Huang, W., et al. (2025). "Enhancing non-invasive early detection of gastric cancer: a critical reflection on exosome ncRNA and machine learning."
Gut. IF=25.8
14.四川大学黄灿华：细胞外囊泡诱导的脂质代谢失调驱动结直肠癌肝前转移微环境的形成
Cao, J., et al. (2025). "Extracellular vesicle-induced lipid dysregulation drives liver premetastatic niche formation in colorectal cancer."
Gut. IF=25.8
15.重庆医科大学基础医学院王溢副教授、赵敬教授联合重庆大学生物工程学院王贵学教授：一种具有中性粒细胞细胞外囊泡伪装的聚合普罗布考纳米制剂，用于治疗脑缺血再灌注损伤
Jia, M., et al. (2025). "A polymerized probucol nanoformulation with neutrophil extracellular vesicle camouflage for cerebral ischemia-reperfusion injury therapy."
Innovation (Camb) 6(4): 100761. IF=25.7
16.首都医科大学：基于工程外泌体的衰老清除疗法通过靶向p21(+)CD86(+) 小胶质细胞减轻中风症状
Yang, J., et al. (2025). "Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21(+)CD86(+) Microglia."
Exploration (Beijing) 5(3): 20240349. IF=22.5
17.中山大学：外泌体来源的长链非编码RNA lnc-FAM72D-3通过MBNL1/FAK轴重塑肝癌细胞骨架促进仑伐替尼耐药
Cao, M., et al. (2025). "Exosome-derived lnc-FAM72D-3 promotes lenvatinib resistance by remodeling hepatocellular carcinoma cytoskeleton via MBNL1/FAK axis."
Drug Resist Updat 82: 101271. IF=21.7
18.温州医科大学花春艳：外泌体与乳腺癌生态系统中代谢重编程的相互作用——新见解与治疗前景
Wang, W., et al. (2025). "Exosomes and metabolic reprogramming crosstalk in breast cancer ecosystem: new insights and therapeutic prospects."
Sci Bull (Beijing). IF=21.1
19.昆明医科大学廖玉辉：具有光触发气体治疗和可控释放G型外泌体功能的多功能DNA水凝胶用于感染性伤口愈合
Ye, Y., et al. (2025). "Multifunctional DNA hydrogels with light-triggered gas-therapy and controlled G-Exos release for infected wound healing."
Bioact Mater 52: 422-437. IF=20.3
20.中山大学：牙囊干细胞来源的小细胞外囊泡通过重塑巨噬细胞代谢改善牙髓炎
Tian, J., et al. (2025). "Dental follicle stem cell-derived small extracellular vesicles ameliorate pulpitis by reprogramming macrophage metabolism."
Bioact Mater 51: 179-196. IF=20.3
21.中南大学：经单细胞RNA测序鉴定的、搭载人骨骼干细胞来源外泌体的3D打印先进支架可促进骨软骨再生
Lou, W., et al. (2025). "3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration."
Bioact Mater 51: 231-256. IF=20.3
22.海军军医大学：封装在MXene修饰的甲基丙烯酸明胶（GelMA）水凝胶中的AntagomiR-192-5p工程外泌体通过靶向Olfactomedin 4（OLFM4）促进烧伤创面的上皮化
Liu, W., et al. (2025). "AntagomiR-192-5p-engineered exosomes encapsulated in MXene-modified GelMA hydrogel facilitated epithelization of burn wounds by targeting OLFM4."
Bioact Mater 52: 318-337. IF=20.3
23.【综述】东南大学：面向细胞外囊泡大规模生产的新兴技术
Huang, J., et al. (2025). "Emerging technologies towards extracellular vesicles large-scale production."
Bioact Mater 52: 338-365.IF=20.3
24.【综述】温州医科大学：智能凝聚微滴——仿生设计、材料创新及在生物大分子递送中的新兴应用
Ding, B., et al. (2025). "Smart coacervate microdroplets: biomimetic design, material innovations, and emerging applications in biomacromolecule delivery."
Bioact Mater 52: 244-270. IF=20.3
25.华中科技大学：源自嵌合抗原受体单核细胞的仿生细胞外囊泡用于治疗胶质母细胞瘤，一种高效安全的鼻内给药纳米平台
Cheng, Q., et al. (2025). "Biomimetic extracellular vesicles derived from chimeric antigen receptor monocytes to treat glioblastoma: An efficient and safe intranasal drug delivery nanoplatform."
Bioact Mater 52: 228-243.IF=20.3
26.上海交通大学：电刺激预处理的外泌体可加速骨再生
Chen, J., et al. (2025). "Pretreated exosomes by electrical stimulation accelerate bone regeneration."
Bioact Mater 51: 383-398.IF=20.3
27.重庆医科大学王溢：仿生人参皂苷Rb1与probucol共组装纳米颗粒通过抑制氧化应激、炎症和脂质沉积用于动脉粥样硬化的靶向治疗
Zeng, J., et al. (2025). "Biomimetic Ginsenoside Rb1 and Probucol Co-Assembled Nanoparticles for Targeted Atherosclerosis Therapy via Inhibition of Oxidative Stress, Inflammation, and Lipid Deposition."
ACS Nano. IF=16
28.武汉大学中南医院脑胶质瘤中心李志强教授联合中科院上海药物所程震教授团队：对脑胶质瘤“定向爆破”的近红外II区工程化外泌体诊疗探针
Yu, D., et al. (2025). "NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma."
ACS Nano.IF=16
29.东南大学张天柱：封装脂肪干细胞外泌体补片用于调节炎症和促进组织再生
Tao, Y., et al. (2025). "Adipose-Derived Stem-Cell-Derived Exosomes Encapsulated Patch for Modulating Inflammation and Promoting Tissue Regeneration."
ACS Nano 19(23): 21271-21289. IF=16
30.江南大学化妆品创新中心杨成教授团队联合哈佛大学David A. Weitz院士团队：工程化搭载细胞膜蛋白的脂质体以阻断细胞间黑素体的转移
Liu, C., et al. (2025). "Engineering Liposomes with Cell Membrane Proteins to Disrupt Melanosome Transfer between Cells."
ACS Nano.IF=16
31.台湾嘉义大学：聚苯乙烯纳米塑料通过细胞外囊泡递送的微小RNA改变细菌与宿主的相互作用，从而破坏肠道微环境
Hsu, W. H., et al. (2025). "Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs."
Nat Commun 16(1): 5026.IF=15.7
32.江南大学附属医院袁凤来教授团队：滑膜成纤维细胞衍生的细胞外小泡促进类风湿关节炎的关节软骨细胞凋亡
Zhang, Z., et al. (2025). "Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis."
Bone Res 13(1): 61. IF=15
33.南方医科大学南方医院张小勇、胡彦锋和南方医科大学基础医学院毕恩广：CXCL13过表达可增强CAR-T细胞的抗肿瘤功效和对PD-1阻断剂的应答
Zhou, Y., et al. (2025). "CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD-1 Blockade."
Adv Sci (Weinh): e08095.IF=14.1
34.河北医科大学第三医院张彦荣和河北医科大学药学院樊淼：一种生物正交反应驱动的外泌体消除策略
Zhang, W., et al. (2025). "Enhancing Chemotherapy-Related Immune Responses via Bioorthogonal Metabolic Engineering-Driven Tumor Exosomes Elimination."
Adv Sci (Weinh): e06409. IF=14.1
35.广州医科大学金域检验学院王立富：脆弱拟杆菌来源的外膜囊泡递送miR - 5119并通过靶向程序性死亡配体1（PD - L1）抑制气溶素样蛋白D（GSDMD）介导的中性粒细胞胞外诱捕网形成来缓解结肠炎
Yang, Y., et al. (2025). "Bacteroides Fragilis-Derived Outer Membrane Vesicles Deliver MiR-5119 and Alleviate Colitis by Targeting PD-L1 to Inhibit GSDMD-Mediated Neutrophil Extracellular Trap Formation."
Adv Sci (Weinh): e00781. IF=14.1
36.北京航空航天大学常凌乾/董再再，北京大学肿瘤医院吴楠、首都医科大学附属北京友谊医院陈曦：面向肿瘤转移预防和治疗的纳米细胞芯片
Liu, F., et al. (2025). "A Nano-Electro-Platform Enabling Evolutionary Screening and Remodeling of Tumor Cells for Metastasis Inhibition."
Adv Sci (Weinh): e07684. IF=14.1
37.华中农业大学动物科学技术学院魏泓、陶诗煜联合南京大学医学院附属金陵医院吕腾飞：携带甘油醛-3-磷酸脱氢酶（GAPDH）的约氏乳杆菌来源的细胞外囊泡可通过调节巨噬细胞极化来预防溃疡性结肠炎
Tao, S., et al. (2025). "Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization."
J Adv Res. IF=13
38.东南大学张光远：远程缺血预处理通过MIF/DUSP6/JNK保护肾脏缺血-再灌注损伤
Zhang, N., et al. (2025). "Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis."
J Nanobiotechnology 23(1): 422. IF=12.6
39.南方医科大学黄文华：靶向递送SIRT3-胰岛素纳米外泌体修复心肌缺血再灌注线粒体损伤
Yang, J., et al. (2025). "Nanoscale engineered exosomes for dual delivery of Sirtuin3 and insulin to ignite mitochondrial recovery in myocardial ischemia-reperfusion."
J Nanobiotechnology 23(1): 439. IF=12.6
40.中国农业大学食品学院陈芳/李道通：大麦叶通过植物乳杆菌胞外囊泡减轻致病菌感染引起的结肠炎
Feng, Y., et al. (2025). "Lactobacillus plantarum-derived extracellular vesicles from dietary barley leaf supplementation attenuate Citrobacter rodentium infection and intestinal inflammation."
J Nanobiotechnology 23(1): 426. IF=12.6
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外泌体资讯网 国内外泌体领域进展总结（2025年6月）
