8月份国内新出的细胞外囊泡/外泌体领域论文不完全统计有442篇。IF>10的有93篇；IF>20的有7篇。本期主要内容包括：外泌体药递送、MSC疗法进展、肿瘤免疫增强、空间单细胞、外泌体质控、创面修复提效、神经修复突破、铁死亡调控、早检新方法、生产自动化等方面内容。内容十分丰富，不容错过。外泌体之家
1.【综述】中检院王军志院士、同济大学徐俊教授：基于细胞外囊泡的药物概述——研究现状、质量控制和非临床评价策略
Xu, G., et al. (2025). "Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies."
Signal Transduct Target Ther 10(1): 255. IF=52.7
2.广州中医药大学深圳医院(福田)张天奉团队：间充质干细胞治疗人类疾病——分子机制与临床研究
Han, X., et al. (2025). "Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies."
Signal Transduct Target Ther 10(1): 262. IF=52.7
3.四川大学邱逦团队：超声增强的铂配位聚合物免疫增强剂和基于异源融合膜的多功能肿瘤疫苗纳米平台用于黑色素瘤治疗
Guo, R., et al. (2025). "Ultrasound-enhanced Pt-coordinated polymer immunopotentiators and heterogenic fusion membrane-based multifunctional tumor vaccine nanoplatforms for melanoma treatment."
Signal Transduct Target Ther 10(1): 278. IF=52.7
4.华大生命科学研究院：立体单细胞，基于高密度DNA纳米球图案化阵列的空间增强分辨率单细胞测序技术
Liao, S., et al. (2025). "Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays."
Science 389(6762): eadr0475. IF=45.8 （仅涉及一点外泌体内容）
5.四川大学华西医院朱涛主任医师/周诚研究员团队：TNF-α预处理通过miR - 101b - 3p靶向Nav1.6增强间充质干细胞来源的细胞外囊泡对神经性疼痛的镇痛效果
Zhang, L., et al. (2025). "TNF-α-preconditioning enhances analgesic efficacy of mesenchymal stem cell-derived extracellular vesicle in neuropathic pain via miR-101b-3p targeting Nav1.6."
Bioact Mater 53: 522-539. IF=20.3
6.西安交通大学：乳酸菌细胞外囊泡驱动的释氧光热水凝胶可重塑巨噬细胞并促进血管生成，从而加速糖尿病伤口愈合
Yuan, P., et al. (2025). "Lactobacillus extracellular vesicle-driven oxygen-releasing photothermal hydrogel reprograms macrophages and promotes angiogenesis to accelerate diabetic wound healing."
Bioact Mater 54: 144-158. IF=20.3
7.西安交通大学赵永席：可编程DNA纳米笼实现仿生细胞器网络的自适应时空组织
Hao, P., et al. (2025). "Programmable DNA Nanocages Enable Adaptive Spatiotemporal Organization of Biomimetic Organelle Networks."
Angew Chem Int Ed Engl: e202511909. IF=16.9
8.同济大学吴登龙，孙祖俊和李冬：TERC刺激脂肪酸代谢以促进膀胱癌进展
Chen, C., et al. (2025). "TERC Stimulates Fatty Acid Metabolism to Promote Bladder Cancer Progression."
Cancer Res. IF=16.6
9.南方医科大学：用于脊髓损伤修复中靶向递送和小胶质细胞重编程的细胞外囊泡多维工程
Xiong, W., et al. (2025). "Multidimensional Engineering of Extracellular Vesicles for Targeted Delivery and Microglial Reprograming in Spinal Cord Injury Repair."
ACS Nano. IF=16
10.中山大学孙逸仙纪念医院陈旭：利用基于c-MYC的基因回路平台重编程肿瘤微环境以增强特异性癌症免疫治疗
Zhan, H., et al. (2025). "Reprogramming the tumor microenvironment with c-MYC-based gene circuit platform to enhance specific cancer immunotherapy."
Nat Commun 16(1): 7983. IF=15.7
11.中山大学附属第五医院黄曦团队：由小细胞外囊泡递送的mRNA原位生成的嵌合抗原受体（CAR）巨噬细胞可减轻肺癌转移和复发
Xiao, Y., et al. (2025). "Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles."
Nat Commun 16(1): 7166. IF=15.7
12.中山大学张元庆教授、吴敏昊教授团队/美国杜兰大学胡晔教授团队：通过滚环扩增-扩展显微镜技术实现单个细胞外囊泡成像
Wu, J., et al. (2025). "Single extracellular vesicle imaging via rolling circle amplification-expansion microscopy."
Nat Commun 16(1): 7498.IF=15.7
前期报道：https://www.exosomemed.com/19932.html
13.山东大学齐鲁医学院王群教授研究团队：肥胖相关巨噬细胞通过促进线粒体分裂决定脂肪干细胞铁死亡和内脏脂肪功能障碍
Tao, Y., et al. (2025). "Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation."
Nat Commun 16(1): 7564. IF=15.7
14.中国医科大学罗秋华、蔡爽、韩涛、沈阳药科大学孙进及中国医科大学李鹤然：嵌合外泌体来源的免疫调节剂可恢复淋巴结微环境，增强三阴性乳腺癌免疫治疗效果
Sun, M., et al. (2025). "Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy."
Nat Commun 16(1): 7116. IF=15.7
15.武汉大学泰康生命医学中心周翔：胃癌细胞外囊泡DNA的全基因组甲基化分析揭示细胞间通讯特征
Lin, B., et al. (2025). "Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features."
Nat Commun 16(1): 8084. IF=15.7
16.暨南大学陈敏锋、张冬梅和Oscar Junhong Luo：周细胞通过调节肿瘤局部血管张力和血流动力学来促进转移
Li, X., et al. (2025). "Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics."
Nat Commun 16(1): 7115.IF=15.7
17.南京医科大学郭雪江、Yan Li和东南大学谢卓颖：用于超痕量生物流体中细胞外囊泡 N-糖蛋白质组学分析的功能可调磁纳米链平台
Li, M., et al. (2025). "A functionally tunable magnetic nanochains platform for N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids."
Nat Commun 16(1): 7646. IF=15.7
18.武汉大学陈刚教授和余自力副教授团队：通过“工厂”（FACTORY）技术制造细胞外囊泡，用于临床转化应用的全自动收集技术和最佳设备
Liu, X. C., et al. (2025). "Extracellular vesicle manufacture via FACTORY: fully automated collection technology and optimum machinery for clinical translational applications."
Trends Biotechnol. IF=14.9
19.四川大学华西医院王震玲：铜绿假单胞菌的X射线辐照诱导内外膜囊泡的生物发生，其有潜力作为针对急性肺炎的疫苗
Zhang, L., et al. (2025). "X-Ray Irradiation of Pseudomonas aeruginosa Induces Biogenesis of Outer-Inner Membrane Vesicles With Potential as a Vaccine Against Acute Pneumonia."
J Extracell Vesicles 14(8): e70151. IF=14.5
20.南京医科大学熊晓青、朱国庆：自发性高血压大鼠外膜成纤维细胞来源的Exomeres通过转运骨桥蛋白促进血管重塑
Wang, J. X., et al. (2025). "Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin."
J Extracell Vesicles 14(8): e70146. IF=14.5
21.南方医科大学南方医院胡秀梅、郑磊、南方医科大学珠江医院王倩：含鼠李糖乳杆菌GG衍生的胞壁酰二肽的细胞外囊泡通过激活NOD2 - I型干扰素信号通路抑制单纯疱疹病毒2型感染
Wang, J., et al. (2025). "Extracellular Vesicles Containing MDP Derived from Lactobacillus rhamnosus GG Inhibit HSV-2 Infection by Activating the NOD2-IFN-I Signalling Pathway."
J Extracell Vesicles 14(8): e70152. IF=14.5
22.上海交通大学医学院附属瑞金医院沈坤炜、王铮：靶向小细胞外囊泡中的网蛋白4（RTN4）可对抗三阴性乳腺癌转移并增强免疫治疗效果
Wang, H., et al. (2025). "Targeting Reticulin 4 (RTN4) Within Small Extracellular Vesicles Combats Metastasis and Reinforces Immunotherapy in Triple-Negative Breast Cancer."
J Extracell Vesicles 14(8): e70154. IF=14.5
23.华中科技大学张宇坤：富含USP5的凋亡细胞外囊泡通过阻止E2F1的蛋白酶体降解来调节髓核细胞凋亡和DNA损伤修复
Shi, P., et al. (2025). "USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation."
J Extracell Vesicles 14(8): e70148. IF=14.5
24.华中农业大学管武太/张世海团队：约氏乳杆菌胞外囊泡通过诱导CD36动态棕榈酰化和激活PPARγ信号通路促进乳脂肪合成
Li, Q., et al. (2025). "Extracellular Vesicles From Limosilactobacillus johnsonii Enhance Milk Fat Synthesis by Inducing CD36 Dynamic Palmitoylation and Activating PPARγ Signalling."
J Extracell Vesicles 14(8): e70143. IF=14.5
25.哈尔滨医科大学附属第二医院杨宇团队：网格蛋白轻链B通过双重机制驱动肝细胞癌进展，小细胞外囊泡介导的血管生成和NF-κB-PCLAF信号轴
Sun, X., et al. (2025). "Clathrin Light Chain B Drives Hepatocellular Carcinoma Progression Through Dual Mechanisms: Small Extracellular Vesicle-Mediated Angiogenesis and the NF-κB-PCLAF Signaling Axis."
Adv Sci (Weinh): e08613. IF=14.1
26.复旦大学附属肿瘤医院许蜜蝶、盛伟琪，复旦大学Wang Wenfeng：癌症相关成纤维细胞分泌的外泌体CCT6A与β-连环蛋白相互作用，增强胃癌的化疗耐药性和肿瘤发生能力
Sun, H., et al. (2025). "Exosomal CCT6A Secreted by Cancer-Associated Fibroblasts Interacts with β-Catenin to Enhance Chemoresistance and Tumorigenesis in Gastric Cancer."
Adv Sci (Weinh): e06674. IF=14.1
27.哈尔滨医科大学杨宝峰院士：肿瘤细胞外囊泡加重心肌缺血/再灌注损伤中的线粒体损伤
Mei, Z., et al. (2025). "Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury."
Adv Sci (Weinh): e17493.IF=14.1
28.中国海洋大学韩璐：负载多酚工程外泌体的导电微针重塑糖尿病神经血管微环境以促进慢性伤口愈合
Liu, D., et al. (2025). "Conductive Microneedles Loaded With Polyphenol-Engineered Exosomes Reshape Diabetic Neurovascular Niches for Chronic Wound Healing."
Adv Sci (Weinh): e07974. IF=14.1
29.南京大学鲍浩与刘志红：工程化RGD修饰的调节性T细胞外泌体靶向递送miR-218-5p以激活线粒体自噬并减轻糖尿病肾病中的足细胞损伤
Guo, Z., et al. (2025). "Engineered RGD-Treg-Exos Targeted Delivery of miR-218-5p to Activate Mitophagy and Attenuate Podocyte Injury in Diabetic Kidney Disease."
Adv Sci (Weinh): e12034. IF=14.1
30.香港大学岑浩璋、林海松、郑传忠：一种基于自动化微免疫磁珠的电磁操作系统（MEMOs）用于阿尔茨海默病血液检测
Fan, X., et al. (2025). "An Automated Micro-Immunobeads-Based Electromagnetic Operation System (MEMOs) for Blood Testing of Alzheimer's Disease."
Adv Sci (Weinh): e09376. IF=14.1
31.温州大学孙达副研究员联合重庆大学吴伟教授、国科温州研究院杨秦斯：细胞外囊泡与金属有机框架深度融合，重塑精准医学新范式
Xu, P., et al. (2025). "Synergistic integration of extracellular vesicles and metal-organic frameworks: unlocking new opportunities in disease diagnosis and therapy."
Theranostics 15(16): 8609-8638. IF=13.3
前期报道：https://www.exosomemed.com/19892.html
32.浙江省人民医院牟晓洲：口服递送的天然来源细胞外囊泡：研究进展与临床前景
Guan, X., et al. (2025). "Oral natural extracellular vesicles for biomedical applications: Advances and clinical perspectives."
J Adv Res.IF=13
前期报道：https://www.exosomemed.com/19958.html
33.四川大学王启光/樊渝江:利用自组装双功能外泌体简化软骨靶向微凝胶构建流程以实现骨关节炎的高效协同治疗
Deng, S., et al. (2025). "Self-Assembled Bifunctional Exosomes Simplify Chondrocyte-Targeted Sustained-Release Systems in Decellularized Cartilage Microgels for Synergistic Osteoarthritis Therapy."
Small: e03492. IF=12.1
前期报道：https://www.exosomemed.com/19937.html
34.大连医科大学/江苏省苏北人民医院王静成/费文勇/戴纪杭：人羊膜上皮干细胞外泌体调节软骨细胞铁死亡干预骨关节炎
Wang, X., et al. (2025). "Human Amniotic Epithelial Stem Cell Exosomes Regulate Chondrocyte Ferroptosis through ACTA2-AS1-Targeted Binding to ACSL4 for Osteoarthritis Intervention."
Research (Wash D C) 8: 0814. IF=10.7
前期报道：https://www.exosomemed.com/19927.html
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外泌体资讯网 国内外泌体领域进展总结（ 2025 年 8 月）
